The classes have methods that help the programmer perform common repetitive tasks, e.g. The specification of the NONMEM model is easily set or changed through the model and data file classes while the output from a model fit is accessed through the output file class. The classes of the library are built around NONMEM’s data, model and output files. The library is object oriented and written in the programming language Perl. In this article we describe a programming library, Perl-speaks-NONMEM (PsN), intended for programmers that aim at using the computational capability of NONMEM in external applications. The NONMEM program is the most widely used nonlinear regression software in population pharmacokinetic/pharmacodynamic (PK/PD) analyses.
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